Posts filed under ‘Drugs’

Does aspirin improve fertility?

Aspirin has a range of medicinal properties including acting as an anti-coagulant and anti-inflammatory agent. Recently, there has been a surge of interest in the role of aspirin in promoting pregnancy and decreasing the risk of miscarriage.

A 1997 study found that 100 mg of aspirin improved uterine blood flow.

For treatment of women who have antiphospholipid antibodies (something your doctor would typically diagnose after one or more miscarriages), combination of heparin and aspirin has been shown to improve outcome. However, three trials with aspirin alone failed to reduce pregnancy loss. Antiphospholipid syndrome (APS) is an autoimmune disease that causes problems with blood coagulation. As a result, small blot clots can form and result in recurrent miscarriage.

The majority of studies involving aspirin in women without diagnosed APS have been carried out in women undergoing IVF. Unfortunately, much of the data is conflicting. However, since there is some evidence that aspirin may increase the odds of pregnancy in IVF and potential side-effects are mild, it is recommended that aspirin continues to be used daily during this treatment.

In order to determine whether aspirin can improve the odds of conception and decrease miscarriage rate, a study is currently underway at several sites in the US. The “Effects of Aspirin in Gestation and Reproduction trial“, or EAGeR, will last for 5 years and study 1600 women who will receive either 80 mg of aspirin or a placebo daily. Stay tuned for results of this important study…

Note: All studies have been performed with baby aspirin, approximately 81-100 mg per day. Regular aspirin dose is 300 mg, so if you are going to take aspirin while trying to conceive, make sure that you take only baby aspirin.

5 December 2007 at 8:25 pm 2 comments

Robitussin does what??

A study published in Fertility and Sterlity in 1982 involved treatment of 40 women who had been unable to conceive for at least 10 months, due to hostile cervical mucus. They took 200 mg of guaifenesin (Robitussin, Tussin), three times daily, from cycle day 5 until ovulation was observed based on rise in basal body temperature.

75% of the women had an improvement in the quality of cervical mucus (improved spinnbarkeit and ferning). Of the 23 women with marked improvement, 15 of them became pregnant, after an average of 2.4 months.

Guaifenesin is typically used to increase respiratory tract secretions, and a similar mechanism is believed to occur, improving cervical mucus.

Patients that had NO cervical mucus to begin with were excluded from the study.

Subsequent studies and reviews have concluded that while treatment with guaifenesin is the simplest and cheapest way to improve mucus quality, it is also the least effective. For true cervical factor infertility, ethyinyl estradiol (synthetic estrogen) may be prescribed.

NOTE: Guaifenesin alone should be taken (original Robitussin, Tussin, etc.) Many cold medications contain multiple active drugs, most of which are unsafe during pregnancy or have other side effects. For example, Robitussin-DM contains dextromethorphan.

1 December 2007 at 10:13 am 1 comment


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